Acacia catechu, generally referred to as black cutch, is a deciduous tree from the legume (Fabaceae) household. It’s native to India, different Asian nations and East Africa. A well known medicinal plant, the bark and heartwood extract of black cutch are broadly utilized in Ayurveda and Conventional Chinese language Medication (TCM). Er cha, a TCM remedy for cough, dysentery, indigestion and sores, is ready utilizing the heartwood extract of black cutch. The well-known Ayurvedic pores and skin tonic, khadirarishta, can be ready utilizing elements of black cutch.
Apart from pores and skin situations, natural medicines containing black cutch extracts are used to deal with all kinds of illnesses, together with bronchial asthma, bronchitis, colic, diarrhea, ulcers, anemia and stomatitis (mouth irritation). Latest research have additionally discovered that the bark, heartwood and sap of this handy plant have many pharmaceutical properties, resembling anthelmintic, antihyperglycemic, antipyretic and anti inflammatory actions.
In a latest examine, researchers at Mahatma Gandhi University in India explored the immune-modulating effects of black cutch hardwood extracts. Their aim is to search out plant-derived immunomodulators that may stimulate the immune system or suppress immune response when wanted. The researchers reported their findings in an article printed within the Journal of Ayurveda and Integrative Medication.
The immunomodulatory actions of black cutch
Black cutch has a protracted historical past of use in India, not solely as a medicine for humans but also for animals. Veterinarians who nonetheless follow people drugs typically use extracts from the bark and heartwood of black cutch to deal with a damaged horn. Its sap, in the meantime, is often used to deal with diarrhea and wounds in ruminants. In Kerala, a state in India’s Malabar Coast, individuals additionally drink a decoction created from black cutch heartwood for therapeutic functions.
In keeping with research, the heartwood of black cutch is wealthy in bioactive compounds with medicinal properties. As an example, the catechins, rutin and isorhamnetin present in its heartwood extracts have proven potent antioxidant and free radical-scavenging actions. Different parts, like epicatechin, kaempferol and quercetin, have additionally proven antidiabetic, antimicrobial, anti-inflammatory and anti-cancer actions, to call a couple of.
To find out if black cutch heartwood extract has immunomodulatory properties, the researchers analyzed its impact on phagocytosis, antibody-producing cells within the spleen, delayed kind hypersensitivity (DTH), nitric oxide (NO) manufacturing, TNF-? and IL-10 manufacturing by LPS-stimulated macrophages and splenocyte (white blood cells within the spleen) proliferation.
For his or her in vivo experiment, the researchers handled mice with totally different concentrations of the extract and checked out their antibody manufacturing and immune response. Additionally they handled macrophages and mouse splenocytes with the extract and evaluated its impact on phagocytic exercise. As well as, they appeared on the cells’ NO manufacturing and TNF-a and IL-10 expression to find out anti-inflammatory exercise.
The researchers reported that the black cutch heartwood extract elevated the quantity of antibodies within the blood of handled mice in a dose-dependent method. The extract additionally elevated the variety of antibody-producing cells within the animals’ spleens. This means that the extracts can stimulate humoral (antibody-mediated) immune response. (Associated: Siberian ginseng can potentially modulate immune response.)
In vitro, the extract considerably decreased DTH response to sheep’s pink blood cells (SRBC) however elevated phagocytic response in macrophages. DTH instantly correlates with cell-mediated immunity, and the discount noticed signifies that the first immune response promoted by the black cutch extract was antibody-mediated. Regardless of not favoring T cell-mediated immune response, the extract stimulated phagocytic exercise.
However, the black cutch extract inhibited the discharge of pro-inflammatory TNF-a and the manufacturing of NO, suggesting anti-inflammatory exercise. The indisputable fact that it additionally considerably elevated the manufacturing of IL-10, a signaling protein that limits host immune response to pathogens, additional confirms the extract’s anti-inflammatory results.
Primarily based on these findings, the researchers concluded that black cutch has immunomodulatory effects that may affect humoral, cell-mediated and non-specific immune responses.